Disopyramide



Disopyramide has electrophysiological actions similar to those of quinidine and procainamide but exerts greater anticholinergic effects than either, without antiadrenergic effects. Disopyr­amide has prominent negative inotropic effects, and patients who have evidence of abnormal ven­tricular function should receive the drug either not at all or only with extreme caution.
The role of disopyramide in the treatment of atrial and ventricular arrhythmias is similar to that of quinidine. Like quinidine, it can cause a 1:1 conduction during atrial flutter if the patient is not adequately digitalized. Disopyramide does not alter digitalis metabolism.