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Tocainide



Tocainide is an analogue of lidocaine that undergoes negligible hepatic first-pass metabo­lism and therefore approaches 100 per cent oral bioavailability. It is effective for ventricular tachy­arrhythmias, but its efficacy appears to be less than that of lidocaine. The effect of lidocaine on an arrhythmia may predict the efficacy of tocain­ide on that arrhythmia.




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